5-HTP and the Serotonin Connection

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The amino acid tryptophan, present in protein foods, plays a role in a number of biochemical reactions in the body. Some tryptophan becomes protein, some is converted into niacin (vitamin B3) and some enters the brain to become the neurotransmitter serotonin. Serotonin, a key brain chemical, is responsible for producing, among other things, a feeling of calm and well-being. Three decades of research connects various states of depression and anxiety with altered amounts of serotonin.

In the 1970s and 1980s, tryptophan became a popular nutritional supplement because of its role as a precursor to serotonin. Tryptophan proved to be remarkably effective at alleviating symptoms of depression, but in 1989 the Food and Drug Administration (FDA) banned the retail sale of tryptophan after a contaminated batch from a single Japanese manufacturer caused a serious condition known as eosinophilia-myalgia syndrome (EMS). Although tryptophan itself was not clearly implicated in causing EMS, FDA has steadfastly maintained its ban. Fortunately, another substance has come to light as a natural precursor to serotonin: 5-hydroxytryptophan (5-HTP). Derived from the seed pods of Griffonia simplicifolia, a West African plant, 5-HTP is a close relative of tryptophan and part of the metabolic pathway that leads to serotonin production:

tryptophan —> 5-HTP —> serotonin

The diagram illustrates, simply, that 5-HTP is a more immediate precursor to serotonin than tryptophan is. This means 5-HTP is more directly linked to the production of serotonin than is tryptophan.

So how effective is 5-HTP? Numerous clinical trials have studied the efficacy of 5-HTP for treating depression. One compared 5-HTP to the antidepressant drug fluvoxamine and found 5-HTP to be equally effective.¹ Researchers used the Hamilton Depression Rating Scale and a self-assessment scale to gauge the effectiveness of the two medications. Both scales revealed a gradual reduction in depressive symptoms through time with both medications. Perhaps the most convincing evidence, however, comes from scientists who examined research from around the world on the use of 5-HTP in treating depression. One such researcher, writing in Neuropsychobiology, sums up the findings this way: "Of the 17 reviewed studies, 13 confirm that 5-HTP has true antidepressant properties."²

The effective dose of 5-HTP appears to be between 50 and 500 mg daily.³ Used in combination with other antidepressant substances, however, the effective dose may be even lower. Research shows that some people respond better to lower doses, so I recommend beginning at the low end of the dose range and increasing as necessary. Side effects associated with therapeutic doses of 5-HTP are rare. When they do occur, they are usually limited to mild gastrointestinal complaints.⁴ Compare this to the litany of possible side effects from antidepressant drugs: sedation, fatigue, blurry vision, urine retention, constipation, palpitations, EKG changes, insomnia, nausea, vomiting, diarrhea and mild to severe agitation.⁵

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Researchers looking for other applications for 5-HTP found positive results in fibromyalgia treatment,⁶ weight loss in obese individuals⁷ and a reduction in occurrence of migraine headaches.⁸ Because so many conditions may be affected by serotonin function, it is not surprising to see such a wide range of therapeutic possibilities for 5-HTP.

It appears that 5-HTP may be one of the most helpful natural substances to be discovered in recent years. As with most treatments, the following words of caution apply: 5-HTP may not be appropriate for all types of depression and may not be compatible with all types of medication. Consultation with a health care practitioner is strongly advised.

Source: By David Wolfson, N.D., a physician, nutrition educator and writer as well as a consultant to the natural products industry. Article references here

5-HTP and the Serotonin Connection

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